Testogel

[Gauche]

pbs... Just curious if you knew

 

[Christian]

I'm a student with a healthcare card all my scripts are 5.40

If you go onto cincotta chemist website they will have prices for most things.

 

[azza]

Ok i have low test, all my blood tests were between a low of 7.8 and the highest was 14.1, other 2 were 11.6 and 12.1. This is over a 6 month period, being 39 and training off and on for 20 years with no AAS to date. My GP, once i outlined my case gave me a PBS script for SUS250 which is only 178mg's of the 4 different esters. 1 a month to start off with. Most gp's i get the feeling just want to get you up over the line rather than treat you indefinitely. I have another mate who has a well and truly f**ked thyroid through over 20 years of AAS abuse gets weekly injections of SUS and only pays 28 dollars for 3 amp's. My tests have not been consecutive, you need to have 2 in a row below the scale. I have been quite frustrated at not getting what i know i need and resorted to getting my gear and self injecting, with success. My GP has showed me her obligation and what is required to satisfy the requirements for legitimate scripting. Until i turn 40, which is 5 months, i wont be able to go on the TRT replacement program and will self medicate for now. Hope this info helps. There are clinics, one is based on the Gold Coast which specialise in TRT and HRT and will and do supply body builders needs, it cost's some coin though. I personally would not bother with the creams.

AZZA

 

[Sticky]

Azza, great to hear from you mate.

So where are you at? Currently being treated?

Are you in GC?

 

[Christian]

Transdermal is optimal for most people for try purposes.

Ok i have low test, all my blood tests were between a low of 7.8 and the highest was 14.1, other 2 were 11.6 and 12.1. This is over a 6 month period, being 39 and training off and on for 20 years with no AAS to date. My GP, once i outlined my case gave me a PBS script for SUS250 which is only 178mg's of the 4 different esters. 1 a month to start off with. Most gp's i get the feeling just want to get you up over the line rather than treat you indefinitely. I have another mate who has a well and truly f**ked thyroid through over 20 years of AAS abuse gets weekly injections of SUS and only pays 28 dollars for 3 amp's. My tests have not been consecutive, you need to have 2 in a row below the scale. I have been quite frustrated at not getting what i know i need and resorted to getting my gear and self injecting, with success. My GP has showed me her obligation and what is required to satisfy the requirements for legitimate scripting. Until i turn 40, which is 5 months, i wont be able to go on the TRT replacement program and will self medicate for now. Hope this info helps. There are clinics, one is based on the Gold Coast which specialise in TRT and HRT and will and do supply body builders needs, it cost's some coin though. I personally would not bother with the creams.

AZZA

 

[funks]

Ok so I'm pretty sure I tick most of those boxes and have been thinking there could be something not quite right for a while.

If I am to have "bloodwork" done, what tests should I be asking for?

 

[Gauche]

Everything. Lh and fsh. Test, free test and cortisiol are the main ones. I was reading on another forum the guidelines for gp's to help you with an endocrinologist and apparently if your test low twice in six months gp's can prescribe. I would personally get a test and if low get a referral to an endocrinologist. It's not the cheapest way.

Once I found out I was low I just did a steroid cycle and everything changed and I knew it was my problem.

 

[Christian]

I wouldnt want aother refferal to an endocronologist. They honestly have no idea...

Anyone who

-thinks thyroid problems can and will only be treated with thyroxine
-does not realise the importance of adrenals in the picture of hormonal problems.
-Thinks cushings and addisons is all that exists and nothing in between.
-does not recognise the effects of improper e2 control
-thinks pregnenolone has no effects other then precursor
-thinks someone in there 20's with test scores under 13nmol/l is normal


is a quack...

 

[jbhayman]

WTF.. HOLY SH*& you guys rub testogel on your nuts.. that must take ages for the full sachet... and why?? Read the instructions:

How to use it:
Testogel is for use by adult men only. Do not apply Testogel to the testes, scrotum or penis.


I have been on this for 3 years now (medical condition) and it is OK wouldn't say it is the greatest. Sustanon (like a tetanus shot)..is a crock of shit unless you take it every 2 weeks (did this for 6months and gave up on it). I found you get that kick for the first could of days then it disappears.....Patches are CRAP and cause irritation and are a pain in the arse...

The best solution although i have not taken it is slow release tablets that are implanted under the skin and they last about 6 months.. but I don't want all the scars from the stitches every time i have to get it.... At least testogel i can go off and on and then take double does from time to time when i need a pickup.

I have also taken T-BOMB recently as a natural supplement and it gives good WOOD.. so it must be doing something

Still laughing my arse off that you guys rub it on your nuts ..... HAHHAHa (rolling on the ground laughing)

John

 

[Sticky]

Your an idiot. Did you read the thread?

Obviously not otherwise you would know why applying it to your nuts can be beneficial.

 

[jbhayman]

Your an idiot. Did you read the thread?

Obviously not otherwise you would know why applying it to your nuts can be beneficial.

Did read it.. but u guys are making me laugh... Hahahahha .... so where u get this info from anyway that rubbing it on your nuts works best?? is it proven or heresay?

Heres a real scientific truth to it...



Approximately 10% of the testosterone dose applied on the skin surface from TESTOGEL is
absorbed into the systemic circulation. The surface area of skin contact does not greatly
affect the level of testosterone absorption.
Following percutaneous absorption, testosterone diffuses into the systemic circulation at
relatively constant concentrations during the 24 hour cycle.
Administration of 5 g of TESTOGEL produces an average testosterone concentration
increase in hypogonadic men of approximately 8.7 nmol/L in plasma.

Skin thickness:............ for those that think it is absorbed quicker via the thin skin of the testicles..................

Does skin thickness affect the absorption of Testogel?

R Smith, N Karavitaki & J Wass

Department of Endocrinology, Churchill Hospital, Oxford, UK.

Background: A variety of preparations for testosterone replacement therapy are currently available. Testogel, a transdermal gel, is widely used and considered one of the most convenient. However, a wide variation in the increment of serum testosterone two hours after its application has been reported.

Aim: To investigate whether skin thickness affects the absorption of testogel.

Subjects and methods: Fourteen patients (mean age 55.4 years, range 19–75 years) diagnosed with hypogonadism (mean year 2000, range 1985–2006), seven of which had acromegaly, (3 cured, 4 not cured) were studied. All were using testogel 50 mg daily. About 22–24 h following previous day gel application blood samples for serum testosterone were taken (between 0900 and 1000 h). The timing of sampling was prior to the gel being applied (time 0), 2 h after application of the gel (time 120) and 4 h after application (time 240). Gel was applied to either top of arm or back of shoulder. Skin fold thickness was measured using skin fold calipers on the back of the hand (mean 3.1, range 2–5).

Results: Mean serum testosterone at time 0 was 10.51 nmol/l (4.6–21.3), at time 120 was 13.47 nmol/l (5.6–26.3) and at time 240 was 18.59 nmol/l (8.3–42.9). There was significant correlation between serum testosterone at time 0 and % increase at time 240 (P=0.03). There was no significant correlation between skin fold thickness and the % increase of serum testosterone at time 240(P=0.8). The increment in serum testosterone at time 240 in patients with acromegaly was not significantly different with the one observed in patients without acromegaly (matched for BMI and serum testosterone at time 0).

Conclusion: Serum testosterone levels at time 240 is not correlated by skin thickness following application of testogel. Therefore this preparation could be considered as a form of testosterone replacement therapy for patients with thicker skin as a result of acromegaly.

Something i learned :

Carcinogenicity and Mutagenicity

•

Sex hormones are known to promote the growth of certain hormone-dependent tissues and
tumours. Subcutaneous implantation of testosterone produced cervical-uterine tumours in
female mice, which metastasised in some cases. Metastasising prostatic adenocarcinomas
occurred in male rats after chemical induction and subcutaneous implantation of testosterone.
Testosterone promotes hepatocarcinogenesis in mice and rats.

Hepatocellular carcinoma has been reported in patients receiving long-term therapy with
androgens. Chronic androgen deficiency is a protective factor for prostatic disease and
hypogonadal men receiving androgen replacement therapy require surveillance for prostatic
disease similar to that recommended for eugonadal men of comparable age.

The genotoxic potential of testosterone has not been fully investigated, although limited data
available to date suggest that it is not genotoxic.

Please I would like to know otherwise...as I am someone that uses this all the time due to a medical condition. If you are going to prove your point that it works I would like to see some documented evidence of this ( I am a genetics scientist so that goes without question)

John

 

[Sticky]

Noobs will jump in with some science stuff, I wont even try.

Its applied to the scrotum not for the skin thickness (in an aim for higher testosterone), its because of the increased DHT levels.

 

[jbhayman]

Noobs will jump in with some science stuff, I wont even try.

Its applied to the scrotum not for the skin thickness (in an aim for higher testosterone), its because of the increased DHT levels.

....... yeah but the stuff enters the blood stream and goes systemic ... so location of application does not enter the equation as far as I am aware and from the scientific literature.

Love for you to prove me wrong..I would convert.. but at this stage I am stil LMAO

John

 

[Christian]

Noobs will jump in with some science stuff, I wont even try.

Its applied to the scrotum not for the skin thickness (in an aim for higher testosterone), its because of the increased DHT levels.

Im not even going to bother... Im over stuff like this sticky. YOu dont have to prove anything to anyone. The internet is full of uneducated people... You sort of get over it.

Let him rub it into his abdomen where the largest amount of aromatase is.

If he knew that the skin acted as a resevoir then he would know that if the skin contained 5-a-reducatse or aromatse then naturally it would react with the enzymes present there.

Skin thickness has alot to do with it so does blood flow... Hypo thyroid patients generaly dont get good results with gels due to the thickening and drying of the skin.

 

[jbhayman]

Im not even going to bother... Im over stuff like this sticky. YOu dont have to prove anything to anyone. The internet is full of uneducated people... You sort of get over it.

Let him rub it into his abdomen where the largest amount of aromatase is.

If he knew that the skin acted as a resevoir then he would know that if the skin contained 5-a-reducatse or aromatse then naturally it would react with the enzymes present there.

Skin thickness has alot to do with it so does blood flow... Hypo thyroid patients generaly dont get good results with gels due to the thickening and drying of the skin.

So there is no skin on your testies? yeah right.. I am yet to see your point....or evidence for doing this.. I am actually interested...

Cellular and tissue location.......

The enzyme is located in the endoplasmic reticulum of the cell and its activity is regulated by tissue specific promoters that are in turn controlled by hormones, cytokines, and other factors. The principal action of the enzyme transforms androstenedione to estrone and testosterone to estradiol. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, endometrium as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer.

From what I can see Aromatase over-expression models show highest levels of expression in the testies...? In an ove-rexpression induced mouse model mind u....

The biological significance of estrogen-induced testicular tumorigenesis has been suggested by the in vivo model overexpressing aromatase transgenic mice (19). Half of these males were infertile and some of them showed larger than normal testis and Leydig cell hyperplasia/ Leydig cell tumor. Furthermore, aromatase was markedly immunolocalized in the cytoplasm of interstitial cells, and its immunoreactivity appeared to be strongest in the testes with more advanced stages of neoplasia. The same transgenic animals exhibited circulating estrogen levels at least twice higher than those of control animals, and the levels of aromatase mRNA in their testicular tissues were fourfold higher when compared with controls. It is worth mentioning how ER protein in testicular tissue of aromatase transgenic animals was very high with respect to the undetectable levels of control animals. So the authors suggest how an enhanced synthesis of estrogens in tumoral tissues led to an upregulation of ER expression.

I'll will also ask my Endo.. He is one of Victorias leading Endos..

 

[Gauche]

Why can't mods ban idiots?

There is no fat on your nuts big fella! Except that one above it that bars up sometimes.

The endo says you have a lower conversion to estrogen as there is no fat on your nuts. He also said there are more receptors there.

So what if we like rubbing our nuts every morning? Why's that funny? I can see how a 14 year old may find that funny. Personally any excuse to rub my nuts is a good excuse

 

[azza]

Azza, great to hear from you mate.

So where are you at? Currently being treated?

Are you in GC?

Hey how are you? My treatment has ceased, i am self medicating.
Right now i do the following as part of a challenge i am doing on another forum for a board sponsor.

For 12 weeks the following.

1x Anadrol 50 tablet a day for 4 weeks then 2 tabs day for 2 weeks for 100mg total.

2 injections a week

Test cyp 400mg week
Bold 400mg week

PCT is Clomid and i have Noladex as well.

3 weeks are up and i am up 5kg/ half water.

AZZA

 

[azza]

Oh and i still dont like the gels. However i do rub my nuts, often.

AZZA

 

[Sticky]

Sounds like a decent cycle. Did you have bloods done before hand? Liver function? Adrol is pretty harsh.

Are you using HCG also? It makes coming off your gear A LOT easier for most people.

 

[Sticky]

Oh and i still dont like the gels. However i do rub my nuts, often.

AZZA