There are two words here that are causing or that are the cause of this slight confusion as I see it. When Andy wrote his comment, he was careful to use the word "system". Even though he did not explain there and there what he was alluding to by his usage of this term, his overall comment made it crystal clear that he was referring to the nervous system and not the muscular system.
As you can see, Andy is focusing on the nerves, whilst Rugby88 is talking muscles.
So yes, if one was to train with high intensity on a split routine, even though as Rugby88 suggested that due to this routine being of the "split" type in comparison with a full body routine, one would suffer, not muscular wise, but rather overall nervous system wise, which would ultimately eat deep into one's ability to recover fully, unless one is using steroids in order to compensate for that lack of and much required overall recovery.