The Question: If you were looking to build muscle as fast as you can, how many sets per bodypart and per workout would you perform? What rep range (or ranges) would you use per set? Give detailed reasons why you believe these ranges are the best, and use as much personal experience AND scientific proof as you can.
BONUS QUESTION: What is the most muscle (not just weight) that a person can gain naturally in 12 weeks? What is the average amount that a person could expect to gain with a good workout, diet, and supplement plan?
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Bodybuilders have known intuitively for decades that high volume training is the quickest way to big muscles. When bodybuilding split from Olympic weightlifting in the 1940s, most serious musclemen began training with higher reps and multiple sets (Fair, 1999). It's not because they "felt like it". It's because they saw that it worked.
Exercise science has come a long way since the 1940s. It's no longer a matter of "seeing is believing". We're now able to pinpoint why higher reps and multiple sets work so well at a biological level.
I'll begin by summarising (briefly) how weight training makes muscles grow.
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Grow Baby, Grow![]()
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Muscle growth (hypertrophy) is caused by a buildup of proteins. Protein buildup can happen in three ways (Booth & Thomason, 1991):
Weight training causes microtrauma (tiny tears in muscle fibres)(McDonagh et al, 1984; Gibala et al, 2000). The body responds to the damage by increasing the amount of protein going into the muscles. This continues for up to two days after weight training (Gibala et al, 1995b).
- The amount of protein going into the muscle increases
- The amount of protein wasted from the muscle decreases
- Both 1 and 2
The rate of repair and muscle growth is also positively affected by testosterone and other hormones (Kraemer et al, 1990; Adams, 1998). Weight training increases the release of these muscle-building hormones in your body (Raastad et al, 2000).
The rate of hypertrophy that occurs during this "healing" process depends on the type of muscle fibre involved. Fast twitch fibres respond better than slow twitch fibres (Alway et al; McCall et al, 1996). Individuals with more fast twitch fibres will grow bigger, quicker.
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Training for Ultimate Size![]()
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There is an inverse link between strength gains and hypertrophy (Sale, 1992). When you lift weights, your muscles learn to work better (through neural adaptation) and you become stronger. However, your body recruits less muscle fibre the more it adapts (Ploutz et al, 1994). And the less muscle fibre you stimulate, the less you grow.
Trained Olympic lifters, for example, were shown over a two-year period to have significant strength increases with barely noticeable increases in muscle mass (Hakkinen et al, 1988). I had a similar experience when I used AST's Max-OT principals. My strength went up like crazy, but I gained very little size.
Obviously, traditional strength training with low volume and low sets (1-6 reps, 3 or less sets) is not the best approach. Strength training does cause hypertrophy (Hakkinen et al, 1985), but it won't cause maximum hypertrophy.
High volume, multiple set programs (6-12 reps, 3 to 6 sets) have been shown to create greater hypertrophy for two important reasons:
Remember the muscle-building process described in Grow Baby, Grow? Microtrauma stimulates increased protein synthesis, and muscle growth is positively affected by a number of hormones that are released after weight training. High volume, multiple set programs cause more microtrauma and greater hormone secretion-so the end result is more muscle!
- The higher workload is more effective at creating microtrauma because of the extra time under tension and extra number of fibres recruited (Shinohara et al, 1998; Smith & Rutherford, 1995; Moss et al, 1997)
- High volume, multiple set programs are more effective at increasing the body's production of testosterone and growth hormone (Kraemer et al, 1991; Kraemer et al 1990)
This probably explains why I was unimpressed with HIT. Although HIT uses high reps, you only perform one "hardcore" set per bodypart. I actually lost muscle and began to feel like I didn't even train!
Now, there's one thing you should be aware of. High volume and multiple sets might pack on muscle quickly, but you shouldn't ONLY train this way. There's something called the "general adaptation syndrome", which means your body will adapt to the program very quickly and you'll run into a massive plateau (Selye, 1976).
An effective science-based way to pack on muscle quickly is to use a periodised routine that emphasises high volume and multiple sets. The periodic variation lets you alter the sets and reps of the program to boost muscle growth and recovery (Potteiger et al, 1995). Sets and reps can be varied per exercise, per workout or per week.
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HST is an example of a routine that periodises on a per-exercise basis (i.e HST uses rep ranges between 2-15 for every exercise). I made good size gains using HST, but I didn't become a big fan of using such varied rep ranges each workout. I thought I could have been more productive. To me, HST felt like doing two half-arsed workouts in one session, with one aimed at hypertrophy and the other targeting strength. Then I started periodising on a per-workout basis. I now workout with a 2:1 hypertrophy:strength rotation. This means that I do 2 hypertrophy workouts (8-12 reps, 6 sets) for every 1 strength workout (4-6 reps, 3 sets). It looks like a little something like this (using back and biceps day as an example):
Got the idea? I've found that, by using the 2:1 rotation, I can give maximal attention to training each characteristic. Emphasising high volume, multiple set training gives me the quickest progression in muscle size.
- Monday (Back and biceps)
Hypertrophy Thursday (Back and biceps)
Hypertrophy
Monday (Back and biceps)
Strength
Slotting in a strength day helps me lift more on my hypertrophy days. Lifting more weight for higher reps makes my muscles bigger. And so the circle of growth continues!
But what rep range for toning?