BoyFromAus
New member
this link below is quite interesting. It talks about Aromatase Inhibitors (in particular) 6-OXO.
http://bodybuilding.ultimatefatburner.com/6-oxo-review.html
There was an 8 week study done on subjects who did resistance training and tried to keep their diet consistent.
the group who dosed with a regular dose (300mg) of 6-OXO had a significant rise in free testosterone total testosterone, DHT and Testosterone : Estrogen ratio. However, despite the significant rise, the subjects did reported very minor changes in body composition over the 8-weeks.
One theory was that even though the rise was significant, it wasn't enough to make body composition changes. However another theory was that it's possible that 6-OXO can both raise testosterone...and interfere with testosterone.
6-OXO and testosterone are of a similar chemical structure. By being chemically similar to testosterone, it could interact with testosterone in a competitive fashion not only at the aromatase enzyme but also at the androgen receptor in muscles. Competition at the androgen receptor would decrease testosterone's ability to bind to the receptor and stimulate muscle growth. This would explain the lack of increased muscle mass with increased testosterone concentrations (Daniel Rohle).
.........
I'd like to hear your opinions on it.. Fadi, Shrek,...?
I'm not too sure on androgen reception as to where it occurs. I saw another study done on Novedex XT where subjects free testosterone increased by 400% but they experienced 3.5% bodyfat loss on average, over the 8 weeks and did not experience increased muscle mass. I'm thinking it could be due to a similar reason that Novedex also binds to androgen receptors..
http://bodybuilding.ultimatefatburner.com/6-oxo-review.html
There was an 8 week study done on subjects who did resistance training and tried to keep their diet consistent.
the group who dosed with a regular dose (300mg) of 6-OXO had a significant rise in free testosterone total testosterone, DHT and Testosterone : Estrogen ratio. However, despite the significant rise, the subjects did reported very minor changes in body composition over the 8-weeks.
One theory was that even though the rise was significant, it wasn't enough to make body composition changes. However another theory was that it's possible that 6-OXO can both raise testosterone...and interfere with testosterone.
6-OXO and testosterone are of a similar chemical structure. By being chemically similar to testosterone, it could interact with testosterone in a competitive fashion not only at the aromatase enzyme but also at the androgen receptor in muscles. Competition at the androgen receptor would decrease testosterone's ability to bind to the receptor and stimulate muscle growth. This would explain the lack of increased muscle mass with increased testosterone concentrations (Daniel Rohle).
.........
I'd like to hear your opinions on it.. Fadi, Shrek,...?
I'm not too sure on androgen reception as to where it occurs. I saw another study done on Novedex XT where subjects free testosterone increased by 400% but they experienced 3.5% bodyfat loss on average, over the 8 weeks and did not experience increased muscle mass. I'm thinking it could be due to a similar reason that Novedex also binds to androgen receptors..