Well what I meant is that the less talking from you the better. If you have to talk, get HER to talk, you listen (and direct the convo to feel-good vibe if it ever gets negative). What you're really doing there is to pick up a girl you don't know and can barely see on a poorly lit dance floor at an impossibly loud club for a meaningful one-night relationship. The more you flap your gum (esp if you're not experienced in this biz - if you were a charmer like ceffo, you wouldn't ask for advice) the more reasons she'll have to reject you. Remember that girls in that scene, because there are so many c0cks on display, actively seek reasons to weed out lame guys as quickly as possible. Don't give them that by saying as little as possible!
If you're after stimulating convos with girls, don't pick up at clubs. That environment is not designed for such things.
Get dancing straight away, enjoy the place, look like you're having a great time with friends. Make eye contact & move in if you get the green light (like ceffo said). You basically have two things in your arsenal to pick up: your physique and how you move your body. That's what girls at clubs look for as well, they're not there to have amazing convos with guys. They're there to get drunk, pop pills, dance, attention-wh0re and maybe hook up with a cute/hot guy. Any talking is done as excuses leading to hook-ups, and you are responsible for providing all the excuses and plausible deniability from A-Z. Once you've seen enough signs that she's attracted to you, take her to somewhere quieter & a little more private. From then on, let your penis take the lead.
All these things (and what ceffo said) are basics. Like lifting, do the basics well and you'll be great. Don't try too hard to be smooth or witty, unless it comes naturally.
There are a million other things, but you'll figure them out as you go along.
Think carefully though about whether you want to meet women that way. Some guys are simply not cut out for that kind of casual yet fiercely competitive hookup scene. You may struggle coming from a past "down to earth fat nice guy".