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D-Aspartic Acid


With Aspartame, I understand that there is evidence from both sides, supporting studies from the FDA and the like and a few medical doctors indicating its an excitotoxin.
 
mine came with a 3g scoop so i was gonna use 3g every morning with brekky.. how would you recommend dosing?
 
mine came with a 3g scoop so i was gonna use 3g every morning with brekky.. how would you recommend dosing?

Yeah thats how I would dose it.
I was advised at the time, if having straight DAA to have 3grams with about 350ml of water.

I'd really be interested to see how you go, keep us updated.
 





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Noobs,

From what I've read, most of these points have previously been raised and debated quite heavily, obviously there are other people who would be concerned and have read these studies.

question for all DAA users - Bodybuilding.com Forums



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Quote:
Originally Posted by BIGNFIT
DAA is metabolized into N-methyl-D-aspartate in the body, and the latter chemical is heavily neurotoxic (neuroscience researchers use it to literally KILL neurons when studying animals).

What is your take on that?

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Patrick Arnold:

Glutamate is also neurotoxic. yet it you ingest grams of it in your whey protein,
toxicity is dose dependent. they use injections of NMDA into specific areas of the brain to induce neurotoxicity. the concentrations utilized are orders of magnitude greater than what you would acheive taking DAA as directed. Remember, DAA is sold by a pharmaceutical company in europe as a supplement. If the toxicity were such an issue there is no way they would be selling the stuff.


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I'd say 99% of people who have used DAA, report higher cognitive mech. and mood enhancement.
 
99% based on what?

The experts @ bodybuilding.com

Over stimulation of the NMDA receptors is not a good thing... People already have problems in society with this we see it constantly... The last thing they need is more stimulation of it.

There are better things to do until we know more...

I.E a jab of test enth at this point in time with the knowledge we have would probably be better for you...

Remember when smoking didnt kill you...

Remember when DDT didnt kill you...

Absence of evidence is not evidenceof absence, and there is enough evidence to say otherwise.
 
99% based on what?

The experts @ bodybuilding.com

Sorry let me clarify, the 99% of user feedback.
Actually PA doesn't post on BB... and sorry but PA is an expert, including Dr P.


Some more comments on DAA from PA.
Originally Posted by Patrick Arnold

we are not injecting DAA into our brains. I have read the studies where they use nmda to induce neuronal death and they produce localized concentrations that are magnitudes greater than could ever be acheived by oral ingestion of DAA at realistic dosages.
Dont forget that DAA is an endogenous substance with a vital neuroendocrine role. Its not some toxin that your body makes as a byproduct or something






Originally Posted by Patrick Arnold

certainly the levels are higher than normal, but they simply do not approach levels (at target areas) seen in studies where NMDA is used as a tool to induce nerve damage
you are entitled to your opinion and if you choose to err on the side of caution and not use the product thats fine. i understand you are not saying "its dangerous" and you are simply asking if i am concerned about the potential.






Originally Posted by Patrick Arnold

d-serine (and cycloserine) is also an agonist at the NMDA receptors. The difference is that it is concentrated in tissues other than the endocrine related ones that DAA and NMDA are. It actually has had alot of research done on it as a treatment for schizophrenia, and at doses of 2-3 grams a day. It is considered thusfar to be safe. You could make the same case that you are making here with DAA with this investigational drug.
I just say this so you dont think i am a nut outside the realm of responsible medical science.






Originally Posted by Patrick Arnold

the italian group that funded the study recommends their daa product be taken for 90 days btw.




Originally Posted by Patrick Arnold

NMDA receptors exist throughout the brain. God (and by god i mean evolution, but god sounds more poignant) didnt put them there to destroy your brain. He put them there to serve an essential function in regards to learning, memory, sexuality etc. etc.

When these receptors are overstimulated then trouble happens. Just like when serotonin receptors get overstimulated you get serotonin syndrome. And with dopamine overexcitation you can get mania and psychosis.

So the question is, are we overstimulating the NMDA receptors? I see no evidence that we are.
 
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I dont see any proof i see alot of

"i said it isnt so it isnt"

Welcome to the world of science that means SWEET FUCK ALL
 
Your right, hard to find proof, but a lot of valid points.
As mentioned before, pure speculation - trust me mate 6 months ago this is all the forums were full of - DAA / Excitotoxin / Neurotoxicity / Increased Prolactin / Increased E etc etc...

Besides I trust what PA and Dr P say, these boys know there shit...

In hindsight, they pretty much brought down a company through one epic thread... Do you remember the Slim Xtreme spiking incident? The Divanil issue as well, I'm sure there were others, just don't remember.
 
Refresh me on the Divanil issue. I think I already left BB.com before that came up.
 


Nope i have no idea what you are tlaking about lol, i dont really care about new products. The strongest people in the world never needed them and neither do a bunch of newbies to the strength game.

Yes there are valid points for all sides... and my point is simply "no one knows" so be cautious...

Take some rp6 instead at least there is good research into it
 

Appreciate your concern

Not a new product, but if your interested in an excellent and epic thread... enjoy

Let's discuss designer stimulants: (S)-diphenyl-2-pyrrolidinyl-methane (serious) - Bodybuilding.com Forums
 
Refresh me on the Divanil issue. I think I already left BB.com before that came up.

95% 3,4-Divanil: have we been scammed for years? - Bodybuilding.com Forums

http://www.prweb.com/releases/2010/01/prweb3519384.htm


Sorry mate, if you don't want to read that garbage, basically:

Don't trust any supplement from a company unless they can supply a COA from an INDEPENDENT LAB and you KNOW that they ALWAYS test their raws, sorry but this also applies to Bulk products sourced in Australia (you know what I'm talking about).
 
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Well we have TGA at least..

Thats very true, however the US has the FDA however you still find 'spiked' supps, such as the above Slim Xreme (Designer Stim), ALRI Restore and Jungle Warfare (PH's - although not controlled in the US, there are labelling laws).
 
Thats very true, however the US has the FDA however you still find 'spiked' supps, such as the above Slim Xreme (Designer Stim), ALRI Restore and Jungle Warfare (PH's - although not controlled in the US, there are labelling laws).

FDA is a fucking joke...