C_T
Kunce of the Year 2015
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Have you ever felt "guilty" or "ashamed" from steroid use?
El Testicle
Goat that feeling
Aspirin:
"Aspirin was the first discovered NSAID. Dose dependent liver injury is accepted as the prevalent mechanism. Liver toxicity rate is very low currently since aspirin has been replaced by paracetamol and ibuprofen in pediatric patients and in various rheumatic diseases."
Ibuprofen:
"Ibuprofen has the highest liver safety profile among NSAIDs and showed no severe liver injury in larger studies. Along with paracetamol and aspirin, it is considered one of the most common over the counter NSAIDs sold in the world."
Diclofenac:
"Diclofenac is probably the most used NSAID in rheumatology. Severe liver reactions and diclofenac hospitalization rate are uncommon. An increase in ALT levels of 3-10 × ULN is observed in 3% of cases." (that increase in ALT is nothing)Source: Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?
"Liver toxicity – Long-term use of NSAIDs, especially at high doses, can rarely harm the liver. Monitoring the liver function with blood tests may be recommended in some cases."
Source: UpToDate
There are specific ones such as lumiracoxib which have had idiopathic hepatotoxicity, but that's completely different.
It's not one of the serious issues with simpler NSAIDs. Just full stop not. Given I actually prescribe people NSAIDs and know what I need to be monitoring and ask about with those, I'd think I know better than you.
"Aspirin was the first discovered NSAID. Dose dependent liver injury is accepted as the prevalent mechanism. Liver toxicity rate is very low currently since aspirin has been replaced by paracetamol and ibuprofen in pediatric patients and in various rheumatic diseases."
Ibuprofen:
"Ibuprofen has the highest liver safety profile among NSAIDs and showed no severe liver injury in larger studies. Along with paracetamol and aspirin, it is considered one of the most common over the counter NSAIDs sold in the world."
Diclofenac:
"Diclofenac is probably the most used NSAID in rheumatology. Severe liver reactions and diclofenac hospitalization rate are uncommon. An increase in ALT levels of 3-10 × ULN is observed in 3% of cases." (that increase in ALT is nothing)Source: Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?
"Liver toxicity – Long-term use of NSAIDs, especially at high doses, can rarely harm the liver. Monitoring the liver function with blood tests may be recommended in some cases."
Source: UpToDate
There are specific ones such as lumiracoxib which have had idiopathic hepatotoxicity, but that's completely different.
It's not one of the serious issues with simpler NSAIDs. Just full stop not. Given I actually prescribe people NSAIDs and know what I need to be monitoring and ask about with those, I'd think I know better than you.
Goosey
.
classic swing and miss there.
C_T
Kunce of the Year 2015
if ive treated thousands of people, how can i be a cleaner? lol, nice try and milking. why does it matter if someone is a doctor, trainer, anything,,, i thought we here for information?
no, seems its about reputation
And before you point out that thing from UpToDate as disagreeing with me, no it isn't. It's the difference between "can, sometimes in some patients" and "will in a significant portion of patients and you need to watch for it". UpToDate is American and focuses fairly heavily on defensive medicine.
C_T
Kunce of the Year 2015
with the lack of respect i'm getting, remind me why i should be helping you?
my job is helping people... i don't come here to help more, you gotta deserve it!
Timeah
Captain Kunce
C_T
Kunce of the Year 2015
do you get a warning or a potential sue notice for disclosing private ip addresses? well? don't dance with the devil unless your ready.
El Testicle
Goat that feeling
Popcorn.gif
This is correct. I was online for that meltdown. No ip address was posted.
