yeah i read all that stuff and was curious also as to why people who were doing the testing actually saw some results and after looking around found that on the usplabsdirect website someone has asked the question and been answered by a rep.
THE ORIGINAL QUESTION
Alright i'm only posting this because I want to here an answer from a USPLabs rep! or even better the damn CEO himself!!
I'm not trying to hate at all, because I love Jack3d, and Anabolic Pump, but seriously this stuff!!!
I did a lot of research on the ingredients in this so called T-Booster and honestly where in this will it do ANYTHING for muscle growth or increase testosterone?
First off, Rhamnus Nakaharai simply catalyzes human LDL oxidation! Which pretty much increases cholesterol. Or is just an antioxident, where does this help with muscle building?
Next, Massularia Acuminate (stem). This MIGHT do something for you! It increases testicular protein, glycogen, etc. Basiclly it enhances normal testicular function, which just stimulates male sexual maturation!! Alright, how does this help?
Last is Nelumbo Nucifera...or a lotus flower. This just preety much treats many kinds of illnesses. Once again where does this help with building muscle?
The "Proprietary Blend" is made of what! Because you stress that most companies hide behind this word and most of the time is just filler!! SO please enlighten me on this and let me know if i missed something somewhere!
THE REPLY FROM REP
Originally Posted by Doherty1
Alright i'm only posting this because I want to here an answer from a USPLabs rep! or even better the damn CEO himself!!
I'm not trying to hate at all, because I love Jack3d, and Anabolic Pump, but seriously this stuff!!!
I did a lot of research on the ingredients in this so called T-Booster and honestly where in this will it do ANYTHING for muscle growth or increase testosterone?
First off, Rhamnus Nakaharai simply catalyzes human LDL oxidation! Which pretty much increases cholesterol. Or is just an antioxident, where does this help with muscle building?
Hi Doherty,
I would be more than happy to answer your most pertinent question of "How will PM contribute to muscle growth?" but first, some clarifications may be in order.
Firstly, on the issue of Rhamnus extract and LDL oxidation. In your research, you were undoubtedly led to the following link:
Antioxidant properties of isotorachrysone isolated... [Biochim Biophys Acta. 1996] - PubMed result
which you seem to have misread, and in particular, the following sentence:
Quote:
On the other hand, isotorachrysone retarded the peroxidation of human low density lipoprotein (LDL) initiated by both aqueous and lipophilic peroxyl radicals. And it also suppressed copper-catalyzed human LDL oxidation, as measured by fluorescence intensity.
To clarify, this sentence means the opposite of how you appear to have interpreted it: that is, it does not catalyze LDL oxidation, but rather inhibits both oxidation and peroxidation of cholesterol. The oxidation of cholesterols, in turn, results in the production of a class of compounds known as "oxysterols," with various toxic, apoptotic (cell death) and pro-inflammatory physiological roles. They are, in other words, not very nice guys.
And while reduction in the expression of oxysterols in striated muscle would have an obvious effect on reducing total oxidative stress, a key component in catabolism, that is not primarily responsible for either Rhamnus or Nelumbo's effect on muscle building. For that, one needs to understand the physiological roles of the Phosphodiesterases, and particular to our herbs here, PDE3 and 4.
The phosphodiesterase proteins are collectively responsible for the hydrolysis (breakdown) of the intracellular messengers cAMP (cylic adenosine monophosphate) and cGMP (cyclic guanosine monophosphate). In turn, these cyclic nucleotides are implicated in a wide range of cellular processes, including vaso-relaxation (impotence drugs competitively inhibit a PDE specific to cGMP, PDE5, in order to relax the veinous structures of the penis), cellular proliferation and differentiation, cardiac rhythm, and in the case of skeletal cAMP, muscle fiber regeneration and proteolysis. So, it goes without saying that PDEs are a key target for inhibitory drugs in a wide range of diseases. But what does this have to do with our herbs, here?
Well, as I said, PDE3 and PDE4 are important to our discussion, as the increased expression of these proteins have been implicated in muscular dystrophy and atrophy. Of course, the mechanism at foot here is the degradation of cAMP, which increases muscle fiber regeneration, and decreases muscle proteolysis (breakdown of amino acids). Subsequently, both Rhamnus and Nelumbo have been found to competitively inhibit both PDE3 and PDE4 - or in other words, they have been found to inhibit that which inhibits muscle growth. Conservatively, I would feel comfortable in claiming they would contribute to muscle growth on these grounds.
Quote:
Next, Massularia Acuminate (stem). This MIGHT do something for you! It increases testicular protein, glycogen, etc. Basiclly it enhances normal testicular function, which just stimulates male sexual maturation!! Alright, how does this help?
To clarify, you argue that increased testosterone has not been shown to positively effect body composition and lean:fat mass ratios?
Hopefully that helps. I would be more than happy to provide further clarification of any kind.[/QUOTE]
Understandably im hesitant to believe something a rep/moderator on the company's forum says all im going by is the reviews people have been putting forward and most of them if not all are positive responses to the supplement. If something in there works ill give it a try, im still waiting on this cheaper/better option Fadi has suggested and ill wait until he's happy to 'spill the beans' as im not sure as to how it would work getting Pink Magic into Aus and im not willing to pay that much to get it over here when i can wait however many months for it to become available here.
