???
I thought they would be even more required for an older chap...
Would he really be "busting his ass for nothing" if test is a little low or whatever? Sure it would probably be harder to make progress, but surely it wouldn't be useless? And what could he do if test was low?
Not that I know anything about hormones...
If he has inadequate hormones,
he has less recovery...
If he has less recovery and continues training then he has less cortisol to reduce inflamation and less testosterone/growth hormone to do repairs... While he is sleeping, less repair is being done to the body as it is being overloaded.
Now you can imagine what happens when more damage is being done then repair capabilities can take care of?
Cortisol is exhausted and increased to the max to deal with all the inflamation. Inflamation triggers cytokines such as TNF-a.
TNF-alpha lowers both testosterone and IGF-1 levels (3) (4), and strenuous exercise elevates TNF-al...pha levels (5). TNF-alpha has also been shown to increase insulin resistance,, which we certainly dont want
Cortisol is a catabolic hormone in itself. So now we have elevated cortisol low GH(through aging) ,IGF-1( through hepatic disruption of igf-1) and low Tetsosterone.(due to aging, death of leydig cells)
Activation of TNF signalling
via the C-Jun Nterminal
kinase (JNK) can inhibit IGF-1 signalling via the
phosphorylation and conformational change in IRS1
downstream of the IGF-1 receptor. Such silencing of IGF-1
signalling in situations where inflammatory cytokines are
elevated has many implications for skeletal muscle [1]
There is increasing evidence that inflammation
contributes to the necrosis of dystrophic myofibres.15,16
When myofibre breakdown and necrosis occurs,
inflammation and associated cytokines are essential for
removal of necrotic tissue and for formation of new skeletal
muscle. Inflammatory cells and a range of cytokines
influence myoblast activation, migration, proliferation,
differentiation and fusion. Strong evidence that
inflammatory cells can contribute to necrosis of healthy
muscle cells[1]
Necrosis is the premature
death of
cells and living
tissue[2]
Of course this is the extreme situation... And it is very possible. So it is possible to say he would be busting his ass for nothing if this was his scenario.
But hey nothing a Blood test and a good Dr cant fix.
1.
Implications of cross-talk between TNF and IGF-1 signalling in skeletal muscle
Miranda D. Grounds,
* Hannah G. Radley,* Bijanka G. Gebski,* Marie A. Bogoyevitch† and Thea Shavlakadze*
*
School of Anatomy and Human Biology, The University of Western Australia, Crawley, WA, Australia and
†
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of
Melbourne, VIC, Australia.
2.http://en.wikipedia.org/wiki/Necrosis
3.Mauduit C, et.al Endocrinology 1998 Jun;139(6):2863-.
4.Lang CH et.al Growth Horm IGF Res 2001 Aug;11(4):250-60.
5.Pedersen BK et. al. Exerc Immunol Rev 2001;7:18-31.
