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Protein Intake and Kidney Function

MaxBrenner

MaxBrenner

New member
This is the most comprehensive peer review on Protein intakes and Kidney -Dietary protein intake and renal function

Study conclusion - Although excessive protein intake remains a health concern in individuals with pre-existing renal disease, the literature lacks significant research demonstrating a link between protein intake and the initiation or progression of renal disease in healthy individuals. More importantly, evidence suggests that protein-induced changes in renal function are likely a normal adaptative mechanism well within the functional limits of a healthy kidney. Without question, long-term studies are needed to clarify the scant evidence currently available regarding this relationship. At present, there is not sufficient proof to warrant public health directives aimed at restricting dietary protein intake in healthy adults for the purpose of preserving renal function.
 
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Independent influence of dietary protein on marke... [Kidney Int. 2010] - PubMed - NCBI

Independent influence of dietary protein on markers of kidney function and disease in obesity.
Friedman AN, Yu Z, Juliar BE, Nguyen JT, Strother M, Quinney SK, Li L, Inman M, Gomez G, Shihabi Z, Moe S.
Source
Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. allfried@iupui.edu
Abstract
Obesity is associated with glomerular hyperfiltration and increased urinary protein excretion, as well as structural and functional changes that lead to kidney disease and failure. Dietary protein mimics obesity's effects on the glomerular filtration rate (GFR) and proteinuria and, in certain circumstances, may have the potential to adversely affect kidney function. Here we tested the hypothesis that dietary protein independently explains elevations in the GFR and proteinuria found in obese persons with a normal serum creatinine. Seventeen patients were randomized in a double-blind, crossover fashion for 1-week periods to high (140 g/day) and low (50 g/day) protein diets with a 1-week washout interval separating these periods. High protein consumption was associated with a very modest but significant increase in the GFR of 5 ± 6 ml/min. Hence, while dietary protein does modulate kidney parameters, it is unlikely to fully account for the elevations in GFR and proteinuria found in obesity.
 
http://www.ncbi.nlm.nih.gov/pubmed/10722779

Do regular high protein diets have potential health risks on kidney function in athletes?
Poortmans JR, Dellalieux O.
Source
Department of Physiological Chemistry, Institute of Physical Education and Kinesiotherapy, Free University of Brussels, Belgium.
Abstract
Excess protein and amino acid intake have been recognized as hazardous potential implications for kidney function, leading to progressive impairment of this organ. It has been suggested in the literature, without clear evidence, that high protein intake by athletes has no harmful consequences on renal function. This study investigated body-builders (BB) and other well-trained athletes (OA) with high and medium protein intake, respectively, in order to shed light on this issue. The athletes underwent a 7-day nutrition record analysis as well as blood sample and urine collection to determine the potential renal consequences of a high protein intake. The data revealed that despite higher plasma concentration of uric acid and calcium, Group BB had renal clearances of creatinine, urea, and albumin that were within the normal range. The nitrogen balance for both groups became positive when daily protein intake exceeded 1.26 g.kg but there were no correlations between protein intake and creatinine clearance, albumin excretion rate, and calcium excretion rate. To conclude, it appears that protein intake under 2. 8 g.kg does not impair renal function in well-trained athletes as indicated by the measures of renal function used in this study
 
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Effect of chronic dietary protein intake on ... [Eur J Clin Nutr. 1996] - PubMed - NCBI

Effect of chronic dietary protein intake on the renal function in healthy subjects.
Brändle E, Sieberth HG, Hautmann RE.
Source
Department of Urology, University of Ulm, Germany.
Abstract
OBJECTIVE:
Relatively little is known about the influence of chronic oral protein intake on the kidney function. In most studies only the effect of a short-term change in protein intake [6-28 days] or the effect of an acute protein load on the glomerular filtration rate was studied. The purpose of this study was to investigate the effect of chronic oral protein intake on endogenous creatinine clearance and on the albumin excretion rate.

DESIGN AND SUBJECTS:
In a prospective study 88 healthy volunteers with normal renal function (32 vegetarians, 12 body-builders with no supplementary protein concentrates, 28 body-builders with supplementary protein concentrates and 16 subjects with no special diet) were examined. In order to investigate the effect of chronic oral protein intake, the participants were on their diet for at least 4 months.

RESULTS:
Endogenous creatinine clearance as a measure for glomerular filtration rate varied between 32 ml/min and 197 ml/min or 34 and 186 ml/min x 1.73 m2, respectively. Nitrogen excretion rate was used as a measure for the daily protein intake, since it is known to correlate linearly with the daily protein intake. Nitrogen excretion rates ranged between 2.66 g/d and 33.93 g/d reflecting a daily protein consumption between 17 and 212 g/d or 0.29 g/kg bw/d and 2.6 g/kg bw/day, respectively. Between nitrogen excretion rate and endogenous creatinine clearance a non linear, highly significant correlation was found showing a saturation with a maximum endogenous creatinine clearance of 181.7 ml/min (dose response curve). A similar correlation was observed between urea excretion rate and endogenous creatinine clearance. Using a model for multiple regression analysis the dependence of the albumin excretion rate on nitrogen excretion rate and endogenous creatinine clearance was examined. Only a significant correlation was found between albumin excretion rate and endogenous creatinine clearance, while the correlation between albumin excretion rate and nitrogen excretion rate was not significant.

CONCLUSION:
This investigation shows that chronic oral protein intake of widely varying amounts of protein is a crucial control variable for the glomerular filtration rate in subjects with healthy kidneys. It is suggested that these changes reflect in part structural changes of the glomerulus and tubules due to chronic protein intake.
 
Just on this topic maxbrenner.

If at the end of the night, Im down about 30 40 G protien, There shoul dbe no issue having a couple scoops of whey? By then im done with the food for the day. Coudlent posibly eat any more.

i probly have and 3 or 4 scoops avg day, I try get most from food though i cant always eat so much.
 
MaxBrenner said:
No Issue at all mate :)

I get about 1/3 of my protein intake (310g per day) from protein powder ;)
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Gidday Max,

I see your taking something like 10plus scoops a day...

I generally have around 2 to 3 scoops a day of WPC... Having read the above... Think I might double it...

And yes I still eat a lot of meat and eggs every day...
 
nazzysmith said:
Gidday Max,

I see your taking something like 10plus scoops a day...

I generally have around 2 to 3 scoops a day of WPC... Having read the above... Think I might double it...

And yes I still eat a lot of meat and eggs every day...
Click to expand...

Haha he isn't taken 310g from powder just about 100g per day. I know this for a fact due to stalking and his previous comments.
 
dave said:
Haha he isn't taken 310g from powder just about 100g per day. I know this for a fact due to stalking and his previous comments.
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LOL.... Thats what I get for not reading the post properly...

Even funnier.... 310 x 3 would be 930gm a day...
 
Dave is correct (even though his methods of finding his information is creepy :D ), I get about 100g of protein from protein powder.

So more like 5 scoops or so.
 
MaxBrenner said:
Dave is correct (even though his methods of finding his information is creepy :D ), I get about 100g of protein from protein powder.

So more like 5 scoops or so.
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You love it, don't try to pretend like you don't just to impress everyone else.
 
Hahaha thanks dave once I impress you I will feel like I've made it :D

You are very sarcastic today mate which I actually enjoy.
 
nobullsupplements said:
Hi MB, would like to see your views on this article: http://www.vivalis.si/literatura/2a02.pdf
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Terrible design and just wow!

Carbohydrate intake drop from usual average of 285 grams down to 19 grams at introduction and to 30 grams at 'maint' phase.

So the decline in calcium and increase in acidity etc will be directly linked with the lower carbohydrate intake. The protein of 170 grams (which was only 30-50 grams of an increase on the usual) has nothing to do with it as the íssues' increased with the decrease in carobhydrate intake.
 
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MaxBrenner said:
So the decline in calcium in increase in acidity will be directly linked with the lower carbohydrate intake. The protein of 170 grams (which was only 30-50 grams of an increase on the usual) has nothing to do with it as the íssues' increased with the decrease in carobhydrate intake.
Click to expand...

Exactly my thoughts - a study on a HPLC diet is different to a study on a HP diet per se
 
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