This is found in Fusion Shut Eye available in Australia.
Subjects: Two hundred ninety five (295) volunteers with mild to moderate sleep
difficulties who came to the Metabolic Institute seeking relief from sleep difficulties.
Intervention: A proprietary blend of extracts of Magnolia officinalis bark and Ziziphus
spinosa seed (Seditol®) characterized as containing a minimum of 2.7% honokiol and
0.1% spinosin.
Outcome Measure: A questionnaire was used by the participants to self-report tolerance
and efficacy following a minimum of two weeks of treatment with one (365 mg) capsule
one hour before bedtime.
Results: None of the participants reported any significant adverse events. Of the 18
participants (6.4%) that had mild complaints, the most common concern (8 individuals)
was of feeling groggy the next morning. Just over half of the participants (53.1%)
received one bottle of Seditol and filled out one questionnaire. Just under half of the
participants (46.9%) requested at least one additional bottle of Seditol and filled out more
than one questionnaire (from 2 to 20; average 4.2 questionnaires). Of the individuals
filling out just one questionnaire, the product was considered relaxing by 86.9%, assisting
in a restful sleep by 82.8% and effective in reducing fatigue due to lack of sleep by
82.8%. The scores were higher for the group that returned more than one questionnaire
but the difference was not significant.
Conclusions: A proprietary blend of extracts of Magnolia officinalis bark and Ziziphus
spinosa seed was well tolerated and subjectively reported to assist individuals with mild
to moderate sleep difficulties.