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0ni
Registered Rustler
Liver Stabil, Liv-52 or Essential Forte
Don't take the t-bol for more than 8 weeks, spend as much time off as you do on
Depends what dosage you're taking though, <700mg a week total orals (not including anavar, it's not really harmful on the liver) and you will be fine as long as you're young, not drinking, in good shape etc
Get regular tests
Don't take the t-bol for more than 8 weeks, spend as much time off as you do on
Depends what dosage you're taking though, <700mg a week total orals (not including anavar, it's not really harmful on the liver) and you will be fine as long as you're young, not drinking, in good shape etc
Get regular tests
0ni
Registered Rustler
I have no idea what either cost
I know blackmore's mens multi contains milk thistle because I use it
It's like $30 for 50 days supply so if you buy the liver support on top of that it wouldn't cost too much + you're done for vitamins
I can't really put a price on a healthy body nor can I say for sure if you will even need it
I guess you just need to take the gamble either way lol
I know blackmore's mens multi contains milk thistle because I use it
It's like $30 for 50 days supply so if you buy the liver support on top of that it wouldn't cost too much + you're done for vitamins
I can't really put a price on a healthy body nor can I say for sure if you will even need it
I guess you just need to take the gamble either way lol
white lion
New member
old thread , but the best liver support i know of is TUDCA.
personally i wont run an a liver toxic oral without it , it shits on milk thistle and the like
Aegis
Polyenylphosphatidylcholine + Tauroursodeoxycholic acid
There are many types of liver injury, but only one is normally associated with the use of oral androgens -- cholestasis. This condition is defined as a failure of normal bile to reach the duodenum, which may be due to a number of different pathological states between the hepatocyte and the ampulla of Vater. When one takes oral androgens (typically methylated at C17a) the physical structure of the hepatocyte is altered -- microfilaments and canaliculi become less contractile. Disruptions in the canalicular bile salt export pump may also occur. This leads to impaired bile flow and the retention of highly cytotoxic hydrophobic bile salts. At low concentrations, these retained bile salts cause apoptosis; at higher concentrations, necrosis and severe liver damage.
This is where AEGIS comes into the picture. It was designed with users of oral androgens in mind, and brings together the best anti-cholestatic ingredients available.
Tauroursodeoxycholic acid:
-Can prevent apoptosis during cholestasis. Toxic bile acids produce apoptosis Via fas- and TRAIL- death receptor mediated pathways. Both are, to some degree, dependent on the translocation of the 'bax' pro-apoptoic molecule from the cytosol of hepatocytes to the cell mitochondria. TUDCA prevents bax translocation, strongly stabilizes mitochondrial membranes, and activates the MAPK pro-survival pathway in hepatocytes. (1) These effects protect hepatocytes from bax-related apoptosis.
-Is a hydrophilic bile acid, and its presence markedly shifts the bile pool towards hydrophilicity, which, to some extent, detoxifies it. When used consistently, especially at pharmacological doses, TUDCA (along with UDCA) eventually becomes the predominant bile acid in the liver and in general circulation. (2)
-Directly stimulates bile secretion via modulating cellular signalling pathways in hepatocytes, such as ERK, src, PKC and others. These signalling pathways generally phosphorylate, or activate, the bile salt export pump (BSEP) and other processes involved in bile export/secretion. (For example, PKC-alpha-mediated secretion of HCO3-.) (3, 4, 5)
Polyenylphosphatidylcholine:
-Stabilizes cellular membranes and dilates bile canaliculi. This former effect has been shown to protect human cells from hydrophobic bile salt induced apoptosis (6), and the latter may serve to counteract the reduction in contractility seen in androgen-induced cholestasis. (7)
-Oral androgen administration may decrease hepatic Na+, K+-ATPase, Ca2+, Mg2+-ATPase and F-actin levels --- all of which may be restored, and even raised, by polyenylphosphatidylcholine administration. (8)
-Is secreted into bile by hepatocytes, where it serves as a major component of the micelles in which bile acids are emulsified. Increased levels of biliary phosphatidylcholine reduces the cytotoxicity of bile acids, whereas phosphatidylcholine-secretion impairment (as is often seen in ABCB4 disease) is characterized by extremely severe cholestatic liver disease. (9)
To summarize: Aegis is highly-potent, highly-specific liver protection for people taking hepatotoxic oral androgens. Superior protection cannot be bought, nor should it be needed.
personally i wont run an a liver toxic oral without it , it shits on milk thistle and the like
Aegis
Polyenylphosphatidylcholine + Tauroursodeoxycholic acid
There are many types of liver injury, but only one is normally associated with the use of oral androgens -- cholestasis. This condition is defined as a failure of normal bile to reach the duodenum, which may be due to a number of different pathological states between the hepatocyte and the ampulla of Vater. When one takes oral androgens (typically methylated at C17a) the physical structure of the hepatocyte is altered -- microfilaments and canaliculi become less contractile. Disruptions in the canalicular bile salt export pump may also occur. This leads to impaired bile flow and the retention of highly cytotoxic hydrophobic bile salts. At low concentrations, these retained bile salts cause apoptosis; at higher concentrations, necrosis and severe liver damage.
This is where AEGIS comes into the picture. It was designed with users of oral androgens in mind, and brings together the best anti-cholestatic ingredients available.
Tauroursodeoxycholic acid:
-Can prevent apoptosis during cholestasis. Toxic bile acids produce apoptosis Via fas- and TRAIL- death receptor mediated pathways. Both are, to some degree, dependent on the translocation of the 'bax' pro-apoptoic molecule from the cytosol of hepatocytes to the cell mitochondria. TUDCA prevents bax translocation, strongly stabilizes mitochondrial membranes, and activates the MAPK pro-survival pathway in hepatocytes. (1) These effects protect hepatocytes from bax-related apoptosis.
-Is a hydrophilic bile acid, and its presence markedly shifts the bile pool towards hydrophilicity, which, to some extent, detoxifies it. When used consistently, especially at pharmacological doses, TUDCA (along with UDCA) eventually becomes the predominant bile acid in the liver and in general circulation. (2)
-Directly stimulates bile secretion via modulating cellular signalling pathways in hepatocytes, such as ERK, src, PKC and others. These signalling pathways generally phosphorylate, or activate, the bile salt export pump (BSEP) and other processes involved in bile export/secretion. (For example, PKC-alpha-mediated secretion of HCO3-.) (3, 4, 5)
Polyenylphosphatidylcholine:
-Stabilizes cellular membranes and dilates bile canaliculi. This former effect has been shown to protect human cells from hydrophobic bile salt induced apoptosis (6), and the latter may serve to counteract the reduction in contractility seen in androgen-induced cholestasis. (7)
-Oral androgen administration may decrease hepatic Na+, K+-ATPase, Ca2+, Mg2+-ATPase and F-actin levels --- all of which may be restored, and even raised, by polyenylphosphatidylcholine administration. (8)
-Is secreted into bile by hepatocytes, where it serves as a major component of the micelles in which bile acids are emulsified. Increased levels of biliary phosphatidylcholine reduces the cytotoxicity of bile acids, whereas phosphatidylcholine-secretion impairment (as is often seen in ABCB4 disease) is characterized by extremely severe cholestatic liver disease. (9)
To summarize: Aegis is highly-potent, highly-specific liver protection for people taking hepatotoxic oral androgens. Superior protection cannot be bought, nor should it be needed.
I got my blood results back yesterday.
My liver ALT was 261, in the start of the bad range when I was 175 kgs, now it's a healthy 189.
I took Milk Thistle for first couple months of lifestyle change and seemed to help my shagged liver.