TheGiftToLift
New member
cheerz haz. good man.
and then you don't wake up till 1pm, don't eat sh*t because you want to die. Go to a cafe and eat half a big breakfast. Go back to bed, then wake up three days later with a wedding band and a wife named Lafonda.
I still have the occasional drink. Nothing to excess but the odd beer or two for mates birthdays and special occaisons.
Spending $400 on alcohol is insane. If you want to alter your state of mind you can do much better than alchol with that budget!
you'll be alright. just make sure to drink enough water and eat enough food. and dont go overboard with the drinking.
The truth about alcohol, fat loss and muscle growth | Intermittent fasting diet for fat loss, muscle gain and health
nice article you may like to read.
your not a professional body builder or have some competition on monday so enjoy yourself. the weight you lose is water weight and comes back on in a few normal days. i think its important to enjoy the social times, sometimes your body need to take a back seat. dont feel to guilty about it.
Insulin-like growth factor (IGF)-1 and IGF-binding protein-1 concentrations in serum of normal subjects after alcohol ingestion: evidence for decreased IGF-1 bioavailability
When alcohol had been ingested, the serum ethanol concentration rose to a peak value of 28.6 ± 0.9 mmol/l (mean ± SEM). The serum IGF-1 level declined significantly toward the end of the 7-h period
Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E
Charles H. Lang, Duanqing Wu, Robert A. Frost, Leonard S. Jefferson, Scot R. Kimball, and Thomas C. Vary
Departments of Cellular and Molecular Physiology and Surgery, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033
The present study examined potential mechanisms for the inhibition of protein synthesis in skeletal muscle after chronic alcohol consumption. Rats were maintained on an alcohol-containing diet for 14 wk; control animals were pair fed. Alcohol-induced myopathy was confirmed by a reduction in lean body mass as well as a decrease in the weight of the gastrocnemius and psoas muscles normalized for tibial length. No alcohol-induced decrease in total RNA content (an estimate of ribosomal RNA) was detected in any muscle examined, suggesting that alcohol reduced translational efficiency but not the capacity for protein synthesis. To identify mechanisms responsible for regulating translational efficiency, we analyzed several eukaryotic initiation factors (eIF). There was no difference in the muscle content of either total eIF2or the amount of eIF2
ethanol; peptide-chain initiation; translation initiation; eukaryotic initiation factors 2, 4E,
Alcohol myopathy: impairment of protein synthesis and translation initiation
This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.
Charles H. Lang,
Department of Cellular and Molecular Physiology (H166), Penn State College of Medicine, Hershey, PA 17033, USA
Received 25 September 2000;
accepted 10 November 2000
Available online 23 April 2001.
Abstract
Alcohol consumption leads to numerous morphological, biochemical and functional changes in skeletal and cardiac muscle. One such change observed in both tissues after either acute alcohol intoxication or chronic alcohol consumption is a characteristic decrease in the rate of protein synthesis. A decrease in translation efficiency appears to be responsible for at least part of the reduction. This review highlights advances in determining the molecular mechanisms by which alcohol impairs protein synthesis and places these observations in context of earlier studies on alcoholic myopathy. Both acute and chronic alcohol administration impairs translational control by modulating various aspects of peptide-chain initiation. Moreover, this alcohol-induced impairment in initiation is associated with a decreased availability of eukaryotic initiation factor (eIF) 4E in striated muscle, as evidenced by an increase in the amount of the inactive eIF4E·4E-BP1 complex and decrease in the active eIF4E·eIF4G complex. In contrast, alcohol does not produce consistent alterations in the control of translation initiation by the eIF2 system. The etiology of these changes remain unresolved. However, defects in the availability or effectiveness of various anabolic hormones, particularly insulin-like growth factor-I, are consistent with the alcohol-induced decrease in protein synthesis and translation initiation.
Author Keywords: Alcohol myopathy; Protein synthesis; eIF4E·eIF4G complex
What about protein synthesis? Strangely enough, the acute effects of alcohol on muscle protein synthesis in normal human subjects are non-existent in the scientific litterature
Jack3d Review(Pre-workout/Fat loss)
I've been trying a wide range of pre-workout supplements but I've never found something worth recommending. Some like the extra pump from NO Xplode and similar nitric oxide based supps, I just don't any use for it.
I was pleasantly surprised by Jack3d. Besides the usual ingredients present in many pre-workout supplements, such as caffeine, creatine, arginine and beta-alanine, it contains 1,3-Dimethylamylamine also known as geranamine. This is a potent stimulant (as far as legal alternatives goes) and this is what provides the oomph in this product. Apparently Geranamine is used as recreational drug in some circles and banned in a few countries. I wouldn't be surprised if we'll see more countries banning it soon as everything that is mildly effective seems to get a ban sooner or later. Shortly after I wrote the supplements guide, Meltdown and Clenbutrx both got banned in Sweden.
Anyway, being somewhat resistant to stims, I started off with the maximum recommended dosage the first time (three scoops). After 5-10 minutes, I could tell that it was working as I got an intense urge to do the dishes. During training, I didn't notice anything out of the norm besides a somewhat uncomfortable back pump after squatting. After training, I had to wait two hours before my appetite returned. I never have problems eating after training, especially not after fasted training, but the thought of food made me queasy. I also noticed some slightly panicky feelings at that point, the kind where you want to crawl out of your own skin. Nothing serious, but for those sensitive to CNS stimulants or prone to anxiety attacks, I would not recommend starting off with the highest dose like I did. However, it seems tolerance develops and within a few days I could use the maximum recommended dosage without any side-effects. Unfortunately, the stimulant effect is also lessened.
In my experience, Jack3d is quite effective, but less so for the purpose it's advertised. I see it's use mainly as an appetite surpressant or stimulant, much like ephedrine. The mechanism by which Jack3d exerts its effect is also similar to ephedrine in that it increases epinephrine/adrenaline, which in turn boosts lipolysis and leads to that "focused" feeling. Or that urge to do something, anything.
Either way you want to use it, for a pre-workout or motivational boost, or appetite surpression, Jack3d works, which is why it ends up on my list of recommended, but certainly not essential, list of supplements.
By the way, I haven't found any studies to back the effectiveness of 1,3-dimethylamylamine for fat loss. If anyone knows of any human trials regarding its use for weight loss or improving cognition, alertness, or anything else for that matter, let me know. I always try to find some scientifical backing for the supplements I recommend but I'm at a loss for this one.
However, alcohol also contributes to a healthier and disease-free life by protecting against Alzheimer's disease, metabolic syndrome, rheumatoid arthritis, the common cold, different types of cancers, depression and many other Western diseases. The list goes on and on.
CONCLUSIONS: Light-moderate and moderate drinkers had less depression in the presence of stress than persons in other more extreme drinking categories.
moderate alcohol consumption may be associated with decreased risk of RCC
Oh and the coffee is your friends and sugar is the alcohol for those people who are retarded.
Alcohol is a scurge on society.
Alcohol is a toxin.
Alcohol burns holes in wallets.
Alcohol serves no purpose.
I haven't had a drink in 17 years save for 1 or 2 occassions.
I will not let those occasions poison me again.
I can show you a million articles that say it is not benefiaial to drink.But that article said it was beneficial to drink?
Haha
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