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free weights are more beneficial, as more muscles are utilized to stabilse your body and working joint,
where as machines tend to do the work for you , machines are alright if you are wanting to isolate a muscle
Definition and growth require different programs not machines.
Using free weights whenever possible is best. It makes use of all the stabilising muscles.
Info I have read recommends using machines only for exercises that can otherwise be dangerous without a spotter (anything with a lot of weight over your head/body).
Also, read that if you're doing burnout/supersets they can be best done on a machine. Perhaps the reason for this is that with a machine you can generally quickly change the weight down and down as you exhaust the muscle progressively more whereas with free weights you'd constantly be needing to change the weights on the rack which can be a pain and difficult if the gym you're at is busy and other people have the weights you want.