The effect of nettle root on dihydrotestosterone (DHT) levels has also made it a treatment for hair loss, as male pattern balding has often been linked to an excess of DHT, as has hair loss in women too. In folklore it was always believed that nettles were an effective treatment for baldness and modern science appears to validate this belief.
Nettle root extract was found to partially block 2 enzymes by researchers such as R. Hartmann. The first is 5-alpha-reductase that when combined with testosterone, produces DHT (dihydrotestosterone). DHT is the hormone responsible for androgenic alopecia hair loss. The second enzyme is aromatase, which makes estrogen. Combining nettle root extract with another herbal agent pygeum has been found to inhibit these two enzymes more effectively than either one alone. It was shown that nettle root extract had to be used at high dosages in order to effective whereas lower doses of pygeum worked well. Prostatonin, the combination product of nettles and pygeum have been used to treat BPH (benign prostatic hypertrophy).
Studies by researchers JJ Lichius and others have shown a reduction in prostate growth in mice when large doses of nettle extract were taken orally. Combining nettle root extracts with
saw palmetto berries in BPH patients reduced the amount of testosterone and estrogen. Conversely, it has been conjectured that nettles can block testosterone from binding to the sex hormone globulin, a carrier protein that binds testosterone and limits its bioavailability in the body. As a result, nettles have been called an aphrodisiac since it may help maintain testosterone levels.
Other uses of Nettles include treatment for arthritis, asthma, kidney, urinary tract infections, and last but not least, baldness.