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melanotan 2 in Australia

isnt it that tanning drug?

If so from memory it was illegal for some reason 5 years ago due to health concerns? (i remember reading it when it was made illegal to import it from the US)

maybe a google is in order
 
melanotan 2 has been shown to increase insulin sensitivity..

If they are worried about health concerns maybe they should sort of look at what people eat or take a walk through a pharmacy..

-n00bs
 
Why bother? Aus peptides you can pick it up but seriously you want to take a drug to tan yourself more?
Posted via Mobile Device
 
Not just tanning...

<H1 lang=en class=title>Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
A. C. Heijboer, A. M. van den Hoek, H. Pijl, P. J. Voshol, L. M. Havekes, J. A. Romijn and E. P. M. Corssmit

Abstract

Aims/hypothesis

The present study was conducted to evaluate the effects of central administration of melanotan II (MTII), a melanocortin-3/4 receptor agonist, on hepatic and whole-body insulin sensitivity, independent of food intake and body weight.

Methods

Over a period of 24 h, 225 ng of MTII was injected in three aliquots into the left lateral ventricle of male C57Bl/6 mice. The animals had no access to food. The control group received three injections of distilled water. Whole-body and hepatic insulin sensitivity were measured by hyperinsulinaemic–euglycaemic clamp in combination with [3H]glucose infusion. Glut4 mRNA expression was measured in skeletal muscle.

Results

Plasma glucose and insulin concentrations under basal and hyperinsulinaemic conditions were similar in MTII- and placebo-treated mice. Endogenous glucose production (EGP) and glucose disposal in the basal state were significantly higher in MTII-treated mice than in the control group (71±22 vs 43±12
xxlarge956.gif
mol·min–1·kg–1, p<0.01). during="" hyperinsulinaemia,="" glucose="" disposal="" was="" significantly="" higher="" in="" mtii-treated="" mice="" (151±20="" vs="">
xxlarge956.gif
mol·min–1·kg–1, p<0.01). in="" contrast,="" the="" inhibitory="" effect="" of="" insulin="" on="" egp="" was="" not="" affected="" by="" mtii="" (relative="" decrease="" in="" egp:="" 45±27="" vs="" 50±20%).="">Glut4 mRNA expression in skeletal muscle was significantly increased in MTII-treated mice (307±94 vs 100±56%, p<>

Conclusions/interpretation

Intracerebroventricular administration of MTII acutely increases insulin-mediated glucose disposal but does not affect the capacity of insulin to suppress EGP in C57Bl/6 mice. These data indicate that central stimulation of melanocortin-3/4 receptors modulates insulin sensitivity in a tissue-specific manner, independent of its well-known impact on feeding and body weight.
</H1>
<H2>Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression
G Li, Y Zhang, JT Wilsey, and PJ Scarpace


The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats. Six-day central infusion of MTII (1 nmol/day) reduced body weight and visceral adiposity compared with ad libitum-fed control and pair-fed groups and markedly suppressed caloric intake in both CH and DIO rats. The anorexic response to MTII was similar in DIO relative to CH rats. MTII induced a sustained increase in oxygen consumption in DIO but a delayed response in CH rats. In both diet groups, MTII reduced serum insulin and cholesterol levels compared with controls. HF feeding increased brown adipose tissue (BAT) uncoupling protein 1 (UCP1) by over twofold, and UCP1 levels were further elevated in MTII-treated CH and DIO rats. MTII lowered acetyl-CoA carboxylase expression and prevented the reduction in muscle-type carnitine palmitoyltransferase I mRNA by pair-feeding in the muscle of DIO rats. Compared with CH controls, hypothalamic MC3 and MC4 receptor expression levels were reduced in DIO controls. This study has demonstrated that, despite reduced hypothalamic MC3/MC4 receptor expression, anorexic and thermogenic responses to MTII are unabated with an initial augmentation of energy expenditure in DIO versus CH rats. The HF-induced up-regulation of UCP1 in BAT may contribute to the immediate increase in MTII-stimulated thermogenesis in DIO rats. MTII also increased fat catabolism in the muscle of DIO rats and improved glucose and cholesterol metabolism in both groups.
</H2>
 
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one of my mates takes this... he went like orange at first but now hes sooo dark.. kinda looks good... but I say just get out in the sun and rub yaself with coconut oil.
 
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