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Health not just genes but what we do with them...

Christian

Active Member, June10MOTM
Public release date: 28-Apr-2010
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Contact: Rod Dashwood
rod.dashwood@oregonstate.edu
541-737-5086
Oregon State University

'Epigenetic' concepts offer new approach to degenerative disease



ANAHEIM, Calif. – In studies on cancer, heart disease, neurological disorders and other degenerative conditions, some scientists are moving away from the "nature-versus-nurture" debate and are finding you're not a creature of either genetics or environment, but both – with enormous implications for a new approach to health.
The new field of "epigenetics" is rapidly revealing how people, plants and animals do start with a certain genetic code at conception. But the choice of which genes are "expressed," or activated, is strongly affected by environmental influences. The expression of genes can change rapidly over time, they can be influenced by external factors, those changes can be passed along to offspring, and they can literally hold the key to life and death.
Some of the newest work in this field was outlined today by researchers from the Linus Pauling Institute at Oregon State University, speaking at Experimental Biology 2010, a professional conference in Anaheim, Calif.
According to Rod Dashwood, a professor of environmental and molecular toxicology and head of LPI's Cancer Chemoprotection Program, epigenetics is a unifying theory in which many health problems, ranging from cancer to cardiovascular disease and neurological disorders, can all be caused at least in part by altered "histone modifications," and their effects on the reading of DNA in cells.
"We believe that many diseases that have aberrant gene expression at their root can be linked to how DNA is packaged, and the actions of enzymes such as histone deacetylases, or HDACs," Dashwood said. "As recently as 10 years ago we knew almost nothing about HDAC dysregulation in cancer or other diseases, but it's now one of the most promising areas of health-related research."
In the case of cancer, tumor suppressor genes can cause cancer cells to die by acting as a brake on unrestrained cell growth. But too much of the HDAC enzyme can "switch off" tumor suppressor genes, even though the underlying DNA sequence of the cell – its genetic structure – has not been changed or mutated. If this happens, cells continue to replicate without restraint, which is a fundamental characteristic of cancer development.
The good news – for cancer and perhaps many other health problems – is that "HDAC inhibitors" can stop this degenerative process, and some of them have already been identified in common foods. Examples include sulforaphane in broccoli, indole-3-carbinol in cruciferous vegetables, and organosulfur compounds in vegetables like garlic and onions. Butyrate, a compound produced in the intestine when dietary fiber is fermented, is an HDAC inhibitor, and it provides one possible explanation for why higher intake of dietary fiber might help prevent cancer.
"Metabolism seems to be a key factor, too, generating the active HDAC inhibitor at the site of action," Dashwood said. "In cancer cells, tumor suppressors such as p21 and p53 often become epigenetically silenced. HDAC inhibitors can help turn them on again, and trick the cancer cell into committing suicide via apoptosis.
"We already know some of the things people can do to help prevent cancer with certain dietary or lifestyle approaches," Dashwood said. "Now we're hoping to more fully understand the molecular processes going on, including at the epigenetic level. This should open the door for new approaches to disease prevention or treatment through diet, as well as in complementing conventional drug therapies."
OSU scientists recently received an $8.5 million grant from the National Cancer Institute to explore these issues, making the LPI program one of the leaders in the nation on diet, epigenetics, and cancer prevention. The positive findings of laboratory research are already being converted to placebo-controlled human intervention trials on such health concerns as colon and prostate cancer, which are among the most common cancers in the United States.
OSU scientists have published a number of studies on these topics in professional journals such as Cancer Research, Cancer Prevention Research, Carcinogenesis, and Seminars in Cancer Biology. Among the most recent findings is that naturally occurring organoselenium compounds in the diet might prevent the progress of human prostate and colon cancer through an HDAC inhibition mechanism.
"Some therapeutic drugs already used for cancer treatment in the clinical setting probably work, at least in part, because they are acting as HDAC inhibitors," Dashwood said. "And what's most intriguing is that HDAC inhibition may affect many degenerative health issues, not just cancer. Heart disease, stroke, bipolar disorder, and even aging may all have links to HDAC/histone alterations.
"In the future, a single HDAC inhibitor conceptually could have benefits for more than one degenerative disease problem."

'Epigenetic' concepts offer new approach to degenerative disease

This is what shits me about people who dont take their health seriously, they dramaticaly effect the health of their children and the future population of the world... If you are one of these people it is probably best that you dont reproduce to save a future person the hassles of bad genes.

Look after yourbody, treat it with respect it was given to you by works you can not even imagine possible... Sit down for 10 minutes and consider what human conciousnes is and how lucky you even have it.

Then vlaue your life cheris it and respect it..
 
The value of life. I think the problem is how undervalued life is. That's an interesting article anyway.
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The value of life. I think the problem is how undervalued life is. That's an interesting article anyway.
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Of course, im immortal.. i treat my body like shit because i dont care look how many i am...
Then your grandchildren have issues.

There is nothing manly about abusing your body it is simply idiotic ignorant and moraly wrong in terms of future generations...
 
It's called learning how to accept people for who they are Noobs. You will learn it a lot when you are working with clients. People will do and continue to do the stupidest things even when they have good information to the contrary. I think you are going have to learn to accept it so you do not explode one day. It's hard but it gets easier.
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It's called learning how to accept people for who they are Noobs. You will learn it a lot when you are working with clients. People will do and continue to do the stupidest things even when they have good information to the contrary. I think you are going have to learn to accept it so you do not explode one day. It's hard but it gets easier.
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Dave you are so right there, my sister in law is a perfect example of this (my brother harpooned and married this one), only a couple of years ago she was 175kg, found it hard to do anything, doc told her if she didnt do anything about it she will not see her kids in their teenage years. She told all of us "what does the doctor know" She has gone on to have medicare funded lap band surgery and only lost 25kg or so in the past fukin year and half as she still goes to Hungry Jacks and suck on thick shakes all day instead of eating good food. It shits me to tears aswell that people will just not open their bloody eyes and stop being so ignorant. She still eats shit, hardly exercises and smokes. Even though the doc has told her she has a death sentence she will not change her ways.
 
Thats an extreme case of what I was talking about. 175kg for a woman is HUGE but hey if she wants to die early because she wants to be that fat then she can go for it. My question is why did she get the lap band if she thinks her weight is not a problem (real words not going to kill her).
 
Thats an extreme case of what I was talking about. 175kg for a woman is HUGE but hey if she wants to die early because she wants to be that fat then she can go for it. My question is why did she get the lap band if she thinks her weight is not a problem (real words not going to kill her).


Denial,

If it isnt hormone related it is a phsycological issue, there is no ifs or buts about it... These people are not happy but they changing is "too hard" its easier to take blood pressure medicaiton get surgery and die young because it iwll never happen to me...

What is sad for me is that ok you want to treat yourself like shit and die yougn be my guest. But you have fmaily and CHILDREN to consider about and that is not fair to them.

Im sorry to hear about your sister i hope she can change her ways if not for her for her children.
 
Denial,

If it isnt hormone related it is a phsycological issue, there is no ifs or buts about it... These people are not happy but they changing is "too hard" its easier to take blood pressure medicaiton get surgery and die young because it iwll never happen to me...

What is sad for me is that ok you want to treat yourself like shit and die yougn be my guest. But you have fmaily and CHILDREN to consider about and that is not fair to them.

Im sorry to hear about your sister i hope she can change her ways if not for her for her children.
Noobs, for the reco
 
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Sounds purerly psychological, congrats to your brother on the wonderul choice. I am all for helping someone if they get like that and genuinely want help. But if you keep it up and think everyone else is an idiot but you then you deserve what happens to you.
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